[HTML][HTML] Evaluation of biological activity of natural compounds: current trends and methods

C Barba-Ostria, SE Carrera-Pacheco… - Molecules, 2022 - mdpi.com
Natural compounds have diverse structures and are present in different forms of life.
Metabolites such as tannins, anthocyanins, and alkaloids, among others, serve as a defense …

[HTML][HTML] Advanced optical imaging for the rational design of nanomedicines

A Ortiz-Pérez, M Zhang, LW Fitzpatrick… - Advanced Drug Delivery …, 2023 - Elsevier
Despite the enormous potential of nanomedicines to shape the future of medicine, their
clinical translation remains suboptimal. Translational challenges are present in every step of …

[HTML][HTML] Drug toxicity assessment: cell proliferation versus cell death

EV Sazonova, MS Chesnokov, B Zhivotovsky… - Cell Death …, 2022 - nature.com
Abstract Analysis of the toxicity of chemotherapeutic drugs is one of the main tasks of clinical
pharmacology. Decreased viability of tumor cells may reflect two important physiological …

[HTML][HTML] Anticancer effects with molecular docking confirmation of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines

M Eldeeb, EF Sanad, A Ragab, YA Ammar… - Biomedicines, 2022 - mdpi.com
The current study investigated the cytotoxic effect of ten sulfonamide-derived isatins,
following molecular hybridization, based on the association principles, on hepatocellular …

[HTML][HTML] 3D bioprinting of polycaprolactone-based scaffolds for pulp-dentin regeneration: Investigation of physicochemical and biological behavior

Z Mousavi Nejad, A Zamanian, M Saeidifar, HR Vanaei… - Polymers, 2021 - mdpi.com
In this study, two structurally different scaffolds, a polycaprolactone (PCL)/45S5 Bioglass
(BG) composite and PCL/hyaluronic acid (HyA) were fabricated by 3D printing technology …

[HTML][HTML] Oxygen generating scaffolds regenerate critical size bone defects

S Suvarnapathaki, X Wu, T Zhang, MA Nguyen… - Bioactive Materials, 2022 - Elsevier
Recent innovations in bone tissue engineering have introduced biomaterials that generate
oxygen to substitute vasculature. This strategy provides the immediate oxygen required for …

[HTML][HTML] Nutritional Value and Biofunctionalities of Two Edible Green Seaweeds (Ulva lactuca and Caulerpa racemosa) from Indonesia by Subcritical Water …

R Pangestuti, M Haq, P Rahmadi, BS Chun - Marine Drugs, 2021 - mdpi.com
Caulerpa racemosa (sea grapes) and Ulva lactuca (sea lettuces) are edible green
seaweeds and good sources of bioactive compounds for future foods, nutraceuticals and …

[HTML][HTML] Quercetin, rutin and quercetin-rutin incorporated hydroxypropyl β-cyclodextrin inclusion complexes

E Başaran, AA Öztürk, B Şenel, M Demirel… - European journal of …, 2022 - Elsevier
Quercetin (Q) and rutin (R) are well known and most studied flavonoids due to their activities
in reduction of inflammation, oxidative damage, platelet aggregation and inhibition of cancer …

The efficient activity of plant essential oils for inhibiting Botrytis cinerea and Penicillium expansum: Mechanistic insights into antifungal activity

P Fincheira, I Jofré, J Espinoza, M Levío-Raimán… - Microbiological …, 2023 - Elsevier
Botrytis cinerea and Penicillium expansum produce deterioration in fruit quality, causing
losses to the food industry. Thus, plant essential oils (EOs) have been proposed as a …

Thermosensitive in situ hydrogels of rivastigmine-loaded lipid-based nanosystems for nose-to-brain delivery: Characterisation, biocompatibility, and drug deposition …

S Cunha, M Swedrowska, Y Bellahnid, Z Xu… - International Journal of …, 2022 - Elsevier
Acetylcholinesterase inhibitors are the most used drugs to manage Alzheimer's disease,
although they show low bioavailability in the brain. In this sense, nasal administration has …