The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Mechanism and regulation of DNA end resection in eukaryotes
LS Symington - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
Coiled‐coils: The long and short of it
L Truebestein, TA Leonard - Bioessays, 2016 - Wiley Online Library
Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …
of some proteins are almost invariant in sequence and length, betraying a structural and …
[HTML][HTML] DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities
Summary MRE11 within the MRE11-RAD50-NBS1 (MRN) complex acts in DNA double-
strand break repair (DSBR), detection, and signaling; yet, how its endo-and exonuclease …
strand break repair (DSBR), detection, and signaling; yet, how its endo-and exonuclease …
Double-strand break end resection and repair pathway choice
LS Symington, J Gautier - Annual review of genetics, 2011 - annualreviews.org
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …
Accurate SAXS profile computation and its assessment by contrast variation experiments
A major challenge in structural biology is to characterize structures of proteins and their
assemblies in solution. At low resolution, such a characterization may be achieved by small …
assemblies in solution. At low resolution, such a characterization may be achieved by small …
Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
LS Symington, R Rothstein, M Lisby - Genetics, 2014 - academic.oup.com
Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
profound impact on the maintenance of genome integrity by facilitating error-free DNA …
End resection at double-strand breaks: mechanism and regulation
LS Symington - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
RecA/Rad51 catalyzed pairing of homologous DNA strands, initiated by polymerization of
the recombinase on single-stranded DNA (ssDNA), is a universal feature of homologous …
the recombinase on single-stranded DNA (ssDNA), is a universal feature of homologous …
Structural basis of homologous recombination
Homologous recombination (HR) is a pathway to faithfully repair DNA double-strand breaks
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …
(DSBs). At the core of this pathway is a DNA recombinase, which, as a nucleoprotein …
Biochemical reconstitution of topological DNA binding by the cohesin ring
Y Murayama, F Uhlmann - Nature, 2014 - nature.com
Cohesion between sister chromatids, mediated by the chromosomal cohesin complex, is a
prerequisite for faithful chromosome segregation in mitosis. Cohesin also has vital roles in …
prerequisite for faithful chromosome segregation in mitosis. Cohesin also has vital roles in …