A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Parkinson's disease (PD) is an advanced neurodegenerative disease (NDD) caused by the
degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age …

Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases

SK Beura, R Dhapola, AR Panigrahi… - Medicinal Research …, 2023 - Wiley Online Library
The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …

Donepezil regulates LPS and Aβ-stimulated neuroinflammation through MAPK/NLRP3 inflammasome/STAT3 signaling

J Kim, H Lee, SK Park, JH Park, HR Jeong… - International journal of …, 2021 - mdpi.com
The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as
therapeutic drugs for Alzheimer's disease (AD), but their effects on LPS-and Aβ-induced …

Activated platelets facilitate hematogenous metastasis of breast cancer by modulating the PDGFR-β/COX-2 axis

Y Tang, C Qian, Y Zhou, C Yu, M Song, T Zhang, X Min… - IScience, 2023 - cell.com
Platelets have been widely recognized as a bona fide mediator of malignant diseases, and
they play significant roles in influencing various aspects of tumor progression. Paracrine …

Comorbidity of anxiety and hypertension: common risk factors and potential mechanisms

T Qiu, Z Jiang, X Chen, Y Dai… - International Journal of …, 2023 - Wiley Online Library
Anxiety is more common in patients with hypertension, and these two conditions frequently
coexist. Recently, more emphasis has been placed on determining etiology in patients with …

[HTML][HTML] Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors

N Moussa, N Dayoub - Saudi Pharmaceutical Journal, 2023 - Elsevier
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …

Eicosanoids in skin wound healing

K Yasukawa, T Okuno, T Yokomizo - International Journal of Molecular …, 2020 - mdpi.com
Wound healing is an important process in the human body to protect against external
threats. A dysregulation at any stage of the wound healing process may result in the …

Carboranes as unique pharmacophores in antitumor medicinal chemistry

Y Chen, F Du, L Tang, J Xu, Y Zhao, X Wu, M Li… - Molecular Therapy …, 2022 - cell.com
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …

Deciphering the mechanisms of regulation of an excitatory synapse via cyclooxygenase-2. A review

K Stachowicz - Biochemical Pharmacology, 2021 - Elsevier
Cyclooxygenase (COX) is a heme-containing enzyme that produces prostaglandins (PGs)
via a pathway known as the arachidonic acid (AA) cascade. Two isoforms of COX enzyme …

Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies

E Studzińska-Sroka, M Bulicz, M Henkel, N Rosiak… - Molecules, 2023 - mdpi.com
Evernia prunastri is a lichen widely distributed in the Northern Hemisphere. Its biological
properties still need to be discovered. Therefore, our paper focuses on studies of E. prunastri …