A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson's disease: beneficial or detrimental effects
Parkinson's disease (PD) is an advanced neurodegenerative disease (NDD) caused by the
degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age …
degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age …
Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases
SK Beura, R Dhapola, AR Panigrahi… - Medicinal Research …, 2023 - Wiley Online Library
The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …
Donepezil regulates LPS and Aβ-stimulated neuroinflammation through MAPK/NLRP3 inflammasome/STAT3 signaling
J Kim, H Lee, SK Park, JH Park, HR Jeong… - International journal of …, 2021 - mdpi.com
The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as
therapeutic drugs for Alzheimer's disease (AD), but their effects on LPS-and Aβ-induced …
therapeutic drugs for Alzheimer's disease (AD), but their effects on LPS-and Aβ-induced …
Activated platelets facilitate hematogenous metastasis of breast cancer by modulating the PDGFR-β/COX-2 axis
Y Tang, C Qian, Y Zhou, C Yu, M Song, T Zhang, X Min… - IScience, 2023 - cell.com
Platelets have been widely recognized as a bona fide mediator of malignant diseases, and
they play significant roles in influencing various aspects of tumor progression. Paracrine …
they play significant roles in influencing various aspects of tumor progression. Paracrine …
Comorbidity of anxiety and hypertension: common risk factors and potential mechanisms
T Qiu, Z Jiang, X Chen, Y Dai… - International Journal of …, 2023 - Wiley Online Library
Anxiety is more common in patients with hypertension, and these two conditions frequently
coexist. Recently, more emphasis has been placed on determining etiology in patients with …
coexist. Recently, more emphasis has been placed on determining etiology in patients with …
[HTML][HTML] Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors
N Moussa, N Dayoub - Saudi Pharmaceutical Journal, 2023 - Elsevier
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …
Eicosanoids in skin wound healing
K Yasukawa, T Okuno, T Yokomizo - International Journal of Molecular …, 2020 - mdpi.com
Wound healing is an important process in the human body to protect against external
threats. A dysregulation at any stage of the wound healing process may result in the …
threats. A dysregulation at any stage of the wound healing process may result in the …
Carboranes as unique pharmacophores in antitumor medicinal chemistry
Y Chen, F Du, L Tang, J Xu, Y Zhao, X Wu, M Li… - Molecular Therapy …, 2022 - cell.com
Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of
benzene. It features special physical and chemical properties, and thus has the potential to …
benzene. It features special physical and chemical properties, and thus has the potential to …
Deciphering the mechanisms of regulation of an excitatory synapse via cyclooxygenase-2. A review
K Stachowicz - Biochemical Pharmacology, 2021 - Elsevier
Cyclooxygenase (COX) is a heme-containing enzyme that produces prostaglandins (PGs)
via a pathway known as the arachidonic acid (AA) cascade. Two isoforms of COX enzyme …
via a pathway known as the arachidonic acid (AA) cascade. Two isoforms of COX enzyme …
Pleiotropic Potential of Evernia prunastri Extracts and Their Main Compounds Evernic Acid and Atranorin: In Vitro and In Silico Studies
E Studzińska-Sroka, M Bulicz, M Henkel, N Rosiak… - Molecules, 2023 - mdpi.com
Evernia prunastri is a lichen widely distributed in the Northern Hemisphere. Its biological
properties still need to be discovered. Therefore, our paper focuses on studies of E. prunastri …
properties still need to be discovered. Therefore, our paper focuses on studies of E. prunastri …