Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

To ward off against the catastrophic consequences of persistent DNA double-strand breaks
(DSBs), eukaryotic cells have developed a set of complex signaling networks that detect …

DNA double‐strand break (DSB) is a serious type of DNA damage and is known to trigger
multiple responses within cells. In these responses, novel relationships among DSB, DSB …

Subcellular compartmentalization contributes to the organization of a plethora of molecular
events occurring within cells. This can be achieved in membraneless organelles generated …

Although long overlooked, it is now well understood that DNA does not systematically
assemble into a canonical double helix, known as B-DNA, throughout the entire genome but …

Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to
the accumulation of mutations and is the driving force for carcinogenesis. Multiple pathways …

DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is
crucial for cell viability and genome integrity. The readout of DSB repair may depend on …

All organisms must safeguard the integrity of their DNA to avoid deleterious consequences
of genome instability, which have been linked to human diseases such as autoimmune …

In all the eukaryotic cells, nucleolytic processing (resection) of a double strand DNA break
(DSB) is a key step to channel the repair of the lesion toward the homologous …