Depressive disorders are among the leading causes of global disease burden, but there has
been limited progress in understanding the causes of and treatments for these disorders. In …

Light and optical techniques have made profound impacts on modern medicine, with
numerous lasers and optical devices currently being used in clinical practice to assess …

Background Light has powerful effects on mood, sleep, and the circadian system. Humans
evolved in an environment with a clear distinction between day and night, but our modern …

Psilocybin shows efficacy to alleviate depression in human clinical trials for six or more
months after only one or two treatments. Another hallucinogenic drug, esketamine, has …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Two adolescent mental health fields—sleep and depression—have advanced largely in
parallel until about four years ago. Although sleep problems have been thought to be a …

Introduction Major depressive disorder is one of the most commonly diagnosed psychiatric
illnesses, and it has a profound negative impact on an individual's ability to function. Up to …

Light plays a pivotal role in the regulation of affective behaviors. However, the precise
circuits that mediate the impact of light on depressive-like behaviors are not well understood …

Artificial lighting is omnipresent in contemporary society with disruptive consequences for
human sleep and circadian rhythms because of overexposure to light, particularly in the …

Objectives The primary objectives of these international guidelines were to provide a global
audience of clinicians with (a) a series of evidence-based recommendations for the …