Challenges and opportunities for celecoxib repurposing

U Bąk, A Krupa - Pharmaceutical Research, 2023 - Springer
Drug repositioning, also known as drug repurposing, reprofiling, or rediscovery, is
considered to be one of the most promising strategies to accelerate the development of new …

Inflammation in obsessive–compulsive disorder: A literature review and hypothesis‐based potential of transcranial photobiomodulation

DRA Coelho, JD Salvi, WF Vieira… - Journal of …, 2024 - Wiley Online Library
Obsessive–compulsive disorder (OCD) is a disabling neuropsychiatric disorder that affects
about 2%–3% of the global population. Despite the availability of several treatments, many …

Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models

S Jeyabalan, L Bala, K Subramanian… - Frontiers in …, 2022 - frontiersin.org
Obsessive-compulsive disorder (OCD) is a chronic and complex psychiatric disorder that
usually includes both obsessions and compulsions. Morinda citrifolia L.(Noni) is a functional …

Efficacy and safety of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists in augmentation with selective serotonin reuptake inhibitors (SSRIs) in the treatment of …

N Eissazade, H Mosavari, S Eghdami, M Boroon… - Scientific Reports, 2023 - nature.com
Obsessive–compulsive disorder (OCD) is the fourth most common mental disorder, and
selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of its pharmacological …

Naproxen adjunct to fluoxetine for moderate‐to‐severe obsessive‐compulsive disorder: A randomized, double‐blind, placebo‐controlled trial

A Shamabadi, Z Motavalian… - Psychiatry and …, 2024 - Wiley Online Library
Aim Current treatments for obsessive‐compulsive disorder (OCD) encounter resistance and
limiting adverse events, necessitating novel therapeutic strategies. This study aimed to …

[PDF][PDF] Negin Eissazade, Hesam Mosavari 2, Shayan Eghdami 3, Mahsa Boroon 4, Faria Ashrafi 5 &

M Shalbafan - Scientific Reports, 2023 - researchgate.net
Obsessive–compulsive disorder (OCD) is the fourth most common mental disorder, and
selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of its pharmacological …

Celecoxib versus placebo as an adjunct to treatment-as-usual in children and youth with obsessive–compulsive disorder: protocol for a single-site randomised …

C Westwell-Roper, JR Best, D Elbe, M MacFadden… - BMJ open, 2022 - bmjopen.bmj.com
Background Cyclooxygenase (COX) enzymes oxidise arachidonic acid to prostaglandins,
which modulate neuronal function and inflammation in the central nervous system …

Efficacy of 5-hydroxytryptamine-3 (5-HT3) antagonists adjuvant therapy for moderate to severe obsessive–compulsive disorder: A systematic review and meta …

N Eissazade, H Mosavari, S Eghdami, M Boroon… - 2023 - researchsquare.com
Background: obsessive–compulsive disorder (OCD) is the fourth most common mental
disorder, and selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of its …

[HTML][HTML] Protocol: Celecoxib versus placebo as an adjunct to treatment-as-usual in children and youth with obsessive–compulsive disorder: protocol for a single-site …

C Westwell-Roper, JR Best, D Elbe, M MacFadden… - BMJ Open, 2022 - ncbi.nlm.nih.gov
Background Cyclooxygenase (COX) enzymes oxidise arachidonic acid to prostaglandins,
which modulate neuronal function and inflammation in the central nervous system …

Does celecoxib with sodium valproate have an augmentation effect on acute mania in bipolar disorder? A double-blind controlled clinical trial in Iran

F Faridhosseini, A Talaei, N Shahini… - International Clinical …, 2023 - journals.lww.com
Inflammatory processes in the brain play a role in acute mania etiopathogenesis. There is
little evidence indicating the efficacy of celecoxib adjuvant therapy in treatmenting of manic …