Vitamin D and systems biology
The biological actions of the vitamin D receptor (VDR) have been investigated intensively for
over 100 years and has led to the identification of significant insights into the repertoire of its …
over 100 years and has led to the identification of significant insights into the repertoire of its …
3D tumor models in urology
J Neuhaus, A Rabien, A Reinhold, L Koehler… - International Journal of …, 2023 - mdpi.com
Three-dimensional tumor models have become established in both basic and clinical
research. As multicellular systems consisting of tumor and tumor-associated cells, they can …
research. As multicellular systems consisting of tumor and tumor-associated cells, they can …
Giant cell tumors with HMGA2:: NCOR2 fusion: Clinicopathologic, molecular, and epigenetic study of a distinct entity
R Perret, Z Malaka, V Velasco… - The American Journal …, 2023 - journals.lww.com
Giant cell tumors (GCTs) with high mobility group AT-Hook 2 (HMGA2):: nuclear receptor
corepressor 2 (NCOR2) fusion are rare mesenchymal tumors of controversial nosology …
corepressor 2 (NCOR2) fusion are rare mesenchymal tumors of controversial nosology …
[HTML][HTML] In vivo RNA-seq and ChIP-seq analyses show an obligatory role for the C terminus of p53 in conferring tissue-specific radiation sensitivity
L Resnick-Silverman, R Zhou, MJ Campbell, I Leibling… - Cell reports, 2023 - cell.com
Thymus and spleen, in contrast to liver, are radiosensitive tissues in which p53-dependent
apoptosis is triggered after whole-body radiation in vivo. Combined RNA sequencing (RNA …
apoptosis is triggered after whole-body radiation in vivo. Combined RNA sequencing (RNA …
Keratin‐positive giant cell‐rich tumors of soft tissue with HMGA2::NCOR2 fusions
MA Weigelt, EM Azzato, GK Habermehl… - Journal of …, 2023 - Wiley Online Library
Background Giant cell tumor of soft tissue (GCT‐ST) is a rare soft tissue neoplasm that is
morphologically similar to but genetically distinct from giant cell tumor of bone. A novel …
morphologically similar to but genetically distinct from giant cell tumor of bone. A novel …
A Catalogue of Structural Variation across Ancestrally Diverse Asian Genomes
JHJ Tan, Z Li, MG Porta, R Rajaby, WK Lim… - Nature …, 2024 - nature.com
Structural variants (SVs) are significant contributors to inter-individual genetic variation
associated with traits and diseases. Current SV studies using whole-genome sequencing …
associated with traits and diseases. Current SV studies using whole-genome sequencing …
Insulin-induced AKR1C3 induces fatty acid synthase in a model of human PCOS adipocytes
RD Paulukinas, TM Penning - Endocrinology, 2023 - academic.oup.com
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. In PCOS,
insulin resistance and hyperandrogenism could drive the increased risk for cardiometabolic …
insulin resistance and hyperandrogenism could drive the increased risk for cardiometabolic …
African American prostate cancer displays quantitatively distinct vitamin D receptor cistrome-transcriptome relationships regulated by BAZ1A
African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D
receptor (VDR) genomic actions have not been investigated in this context. We undertook …
receptor (VDR) genomic actions have not been investigated in this context. We undertook …
Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming
Profound functional switch of key regulatory factors may play a major role in homeostasis
and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with …
and disease. Dysregulation of circadian rhythm (CR) is strongly implicated in cancer with …
Nuclear receptor coregulators in hormone-dependent cancers
Simple Summary Altered nuclear receptor signaling is well-established to contribute to a
range of hormone-dependent cancers and therefore they are therapeutic targets, for …
range of hormone-dependent cancers and therefore they are therapeutic targets, for …