Following fertilization, the two specified gametes must unite to create an entirely new
organism. The genome is initially transcriptionally quiescent, allowing the zygote to be …

The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

Chromatin architecture is fundamental in regulating gene expression. To investigate when
spatial genome organization is first established during development, we examined …

All animal embryos pass through a stage during which developmental control is handed
from maternally provided gene products to those synthesized from the zygotic genome. This …

The control of mRNA stability plays a central role in regulating gene expression. In
metazoans, the earliest stages of development are driven by maternally supplied mRNAs …

Although subcellular mRNA trafficking has been demonstrated as a mechanism to control
protein distribution, it is generally believed that most protein localization occurs subsequent …

The regulation of transcription requires the coordination of numerous activities on DNA, yet
how transcription factors mediate these activities remains poorly understood. Here, we use …

Bivalve molluscs are descendants of an early-Cambrian lineage superbly adapted to
benthic filter feeding. Adaptations in form and behavior are well recognized, but the …

The earliest stages of development in most metazoans are driven by maternally deposited
proteins and mRNAs, with widespread transcriptional activation of the zygotic genome …