Objective To systematically review the literature for studies investigating knee osteoarthritis
(OA) phenotypes to examine what OA characteristics are relevant for phenotyping. Methods …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Purpose To investigate the prevalence of dry eye among all adult age categories and to
discover independent risk factors by investigating a wide range of etiological categories …

In the most recent years, an extraordinary research effort has emerged to disentangle
osteoarthritis heterogeneity, opening new avenues for progressing with therapeutic …

Background Knee osteoarthritis (OA) is among the most common and disabling persistent
pain conditions, with increasing prevalence and impact around the globe. In the US, the …

OA is a multifaceted and heterogeneous syndrome that may be amenable to tailored
treatment. There has been an increasing focus within the OA research community on the …

Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …

Abstract Background The Central Sensitization Inventory (CSI) and Pain Sensitivity
Questionnaire (PSQ) are alternatives to quantitative sensory testing (QST) for inferring …

Osteoarthritis (OA) is a leading cause of chronic pain and disability in older adults, which
most commonly affects the joints of the knee, hip, and hand. To date, there are no …

Objective It is not clear why some individuals develop pain with knee osteoarthritis (OA). We
undertook this study to identify pain susceptibility phenotypes (PSP s) and their relationship …