Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …

Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …

White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating
substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the …

The most definitive classification systems for dementia are based on the underlying
pathology which, in turn, is categorized largely according to the observed accumulation of …

Cerebral small vessel disease (CSVD) is a very common neurological disease in older
people. It causes stroke and dementia, mood disturbance and gait problems. Since it is …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …