Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Our traditional understanding of phenotypic plasticity in adult somatic cells comprises
dedifferentiation and transdifferentiation in the context of tissue regeneration or wound …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult
stem cell populations, which leads to hair greying in most humans and mice,. Current dogma …

Despite the great progress in translational research concerning skin wound healing in the
last few decades, no animal model fully predicts all clinical outcomes. The mouse is the most …

Hair follicles are essential appendages of the mammalian skin, as hair performs vital
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …

Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the
mammalian hippocampus. We used chronic in vivo imaging and followed genetically …

Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal …