Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Interactions between mesenchymal stem cells and the immune system

N Li, J Hua - Cellular and Molecular Life Sciences, 2017 - Springer
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess
immunomodulatory functions that have been investigated as potential treatments in various …

[HTML][HTML] Effects of mesenchymal stem cell-derived exosomes on experimental autoimmune uveitis

L Bai, H Shao, H Wang, Z Zhang, C Su, L Dong, B Yu… - Scientific reports, 2017 - nature.com
We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental
autoimmune uveoretinitis (EAU) in rats. Recently, MSC-derived exosomes (MSC-Exo) were …

Immune privilege and eye‐derived T‐regulatory cells

H Keino, S Horie, S Sugita - Journal of immunology research, 2018 - Wiley Online Library
Certain cellular components of the eye, such as neural retina, are unable to regenerate and
replicate after destructive inflammation. Ocular immune privilege provides the eye with …

ENPP1 immunobiology as a therapeutic target

B Ruiz-Fernández de Córdoba, R Martínez-Monge… - Clinical Cancer …, 2023 - AACR
Abstract ENPP1 (ecto-nucleotide pyrophosphatase/phosphodiesterase) participates in the
hydrolysis of different purine nucleotides in an array of physiologic processes. However …

[HTML][HTML] Membrane particles generated from mesenchymal stromal cells modulate immune responses by selective targeting of pro-inflammatory monocytes

FC Gonçalves, F Luk, SS Korevaar, R Bouzid… - Scientific reports, 2017 - nature.com
Mesenchymal stromal cells (MSC) are a promising therapy for immunological disorders.
However, culture expanded MSC are large and get trapped in the capillary networks of the …

Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes

X Zhang, J Liu, B Yu, F Ma, X Ren, X Li - Graefe's Archive for Clinical and …, 2018 - Springer
Purpose To assess the efficacy of mesenchymal stem cells (MSCs) and MSC-derived
exosomes (MSC-Exos) to promote the healing of large and refractory macular holes (MHs) …

[HTML][HTML] Targeting the immunomodulatory CD73/adenosine system to improve the therapeutic gain of radiotherapy

S De Leve, F Wirsdörfer, V Jendrossek - Frontiers in immunology, 2019 - frontiersin.org
Extracellular adenosine is a potent endogenous immunosuppressive mediator critical to the
maintenance of homeostasis in various normal tissues including the lung. Adenosine is …

[HTML][HTML] Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

X Fu, S Feng, H Qin, L Yan, C Zheng… - Frontiers in Molecular …, 2023 - frontiersin.org
Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-
time and facilitate angiogenesis during retinal development. In certain retinal diseases, the …

Rescuing mesenchymal stem cell regenerative properties on hydrogel substrates post serial expansion

VV Rao, MK Vu, H Ma, AR Killaars… - Bioengineering & …, 2019 - Wiley Online Library
The use of human mesenchymal stem/stromal cells (hMSCs) in most clinical trials requires
millions of cells/kg, necessitating ex vivo expansion typically on stiff substrates (tissue …