Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …

Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and
tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ …

The clinical success of immunotherapy that inhibits the negative immune regulatory pathway
programmed cell death protein 1/PD-1 ligand (PD-1/PD-L1) has initiated a new era in the …

Background The distant metastasis is the primary cause of cancer morbidity and mortality for
bladder cancer (BLCA) paitents. All the recommended therapy for it largely depends on how …

Background Focal adhesion plays an essential role in tumour invasiveness and metastasis.
Hippo component YAP has been widely reported to be involved in many aspects of tumour …

The Hippo signaling pathway regulates cell fate and organ development. In the Hippo
pathway, transcriptional enhanced associate domain (TEAD) which is a transcription factor …

The Hippo pathway is an evolutionary conserved signaling network that regulates essential
processes such as organ size, cell proliferation, migration, stemness and apoptosis …

Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple
signaling pathways. A novel approach to the treatment of PDAC is described, involving the …

The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration
of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely …

Metastasis is responsible for most cancer mortality, but its molecular mechanism has not
been completely understood. In addition to coding genes and miRNAs, the contribution of …