Cyclopropanes, one of the most important strained rings, have gained much attention for
more than a century because of their interesting and unique reactivity. They not only exist in …

Cyclopropanes are one of the most important strained rings existing in various
pharmaceutical products and secondary metabolites. They are also widely used in total …

We describe a hybrid system that realizes cooperativity between an organophotoredox
acridinium catalyst and a chiral chromium complex catalyst, thereby enabling …

Goniothalamin (GTN), a natural compound isolated from Goniothalamus species, has
previously demonstrated cytotoxic activity against several cancer cell lines. However …

Herein, the catalytic asymmetric synthesis of cyclopropyl α-amino carboxylates is reported.
Using a chiral rhodium complex (Rh2 ((R)-BTPCP) 4), the synthesis of a large panel of non …

Multidrug resistance (MDR) in tumors and pathogens remains a major problem in the
efficacious treatment of patients by reduction of therapy options and subsequent treatment …

An integrated batch and continuous flow process has been developed for the gram-scale
synthesis of goniothalamin. The synthetic route hinges upon a telescoped continuous flow …

This review covers the chemistry and biological aspects of goniothalamin-related styryl
lactones isolated from natural sources. This family of secondary metabolites has been …

Overexpression of efflux transporters of the ATP-binding cassette (ABC) transporter family,
primarily P-glycoprotein (P-gp), is a frequent cause of multidrug resistance in cancer and …

Dimeric naphthopyranones are known to be biologically active, however, for the
corresponding monomeric naphthopyranones this information is still elusive. Here the first …