Off-label treatments as potential accelerators in the search for the ideal antifungal treatment of cryptococcosis
V Alves, GRS Araújo, S Frases - Future Microbiology, 2023 - Taylor & Francis
Cryptococcosis is an opportunistic mycosis that mainly affects immunosuppressed patients.
The treatment is a combination of three antifungal agents: amphotericin B, 5-flucytosine and …
The treatment is a combination of three antifungal agents: amphotericin B, 5-flucytosine and …
Future perspectives for cryptococcosis treatment
J Santos-Gandelman, ML Rodrigues… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Cryptococcosis is one of the most devastating human fungal infections. Despite
its impact, none of the standard antifungals were developed after 1990. New, improved, less …
its impact, none of the standard antifungals were developed after 1990. New, improved, less …
Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp
SA Rossi, HC De Oliveira… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Amphotericin B (AmB) is the antifungal with the strongest fungicidal activity, but its use has
several limitations, mainly associated with its toxicity. Although some lipidic and liposomal …
several limitations, mainly associated with its toxicity. Although some lipidic and liposomal …
The atypical antipsychotic quetiapine promotes multiple antibiotic resistance in Escherichia coli
Y Kyono, L Ellezian, YY Hu, K Eliadis, J Moy… - Journal of …, 2022 - Am Soc Microbiol
Atypical antipsychotic (AAP) medication is a critical tool for treating symptoms of psychiatric
disorders. While AAPs primarily target dopamine (D2) and serotonin (5HT2A and 5HT1A) …
disorders. While AAPs primarily target dopamine (D2) and serotonin (5HT2A and 5HT1A) …
[HTML][HTML] Quinoline antimalarials increase the antibacterial activity of ampicillin
Bacterial and malaria co-infections are common in malaria endemic countries and thus
necessitate co-administration of antibiotics and antimalarials. There have long been …
necessitate co-administration of antibiotics and antimalarials. There have long been …
Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort
Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in
particular with cognitive impairment. Female gender, overweight and tobacco smoking have …
particular with cognitive impairment. Female gender, overweight and tobacco smoking have …
Antipsychotic quetiapine alters the mouse fecal resistome by impacting antibiotic efflux, cell membrane, and cell wall synthesis genes
Y Kyono, JD Magboo, EA Daley… - Microbiology …, 2024 - Am Soc Microbiol
The understanding of the antimicrobial activities of non-antibiotic pharmaceuticals is
evolving, with growing interest in their implications for antimicrobial resistance (AMR) in gut …
evolving, with growing interest in their implications for antimicrobial resistance (AMR) in gut …
Drug repositioning of benzimidazole anthelmintics in the treatment of cryptococcosis: a review
EAM Oliveira, GF Ferreira, KL Lang - Medicinal Chemistry Research, 2022 - Springer
Cryptococcosis is a systemic mycosis caused by pathogenic yeasts of the Cryptococcus
genus and the second biggest cause of morbidity and mortality in individuals with AIDS …
genus and the second biggest cause of morbidity and mortality in individuals with AIDS …
The future of metronomic chemotherapy: experimental and computational approaches of drug repurposing
YA Abdelrady, HS Thabet, AM Sayed - Pharmacological Reports, 2024 - Springer
Abstract Metronomic chemotherapy (MC), long-term continuous administration of anticancer
drugs, is gaining attention as an alternative to the traditional maximum tolerated dose (MTD) …
drugs, is gaining attention as an alternative to the traditional maximum tolerated dose (MTD) …
Changes in inflammation with treatment for bipolar II depression: pilot trial data on differential effects of psychotherapy and medication
JG Fiedorowicz, JM Cyranowski, Z Liu… - Neurology, Psychiatry and …, 2019 - Elsevier
Objectives Limited prospective data, mostly focused on bipolar I disorder, suggests that pro-
inflammatory cytokines are elevated in abnormal mood states. We evaluated whether …
inflammatory cytokines are elevated in abnormal mood states. We evaluated whether …