Communication between cells reaches its highest degree of specialization at chemical
synapses. Some synapses talk in a'whisper'; others' shout'. The'louder'the synapse, the more …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

During development cells and tissues undergo changes in pattern and form that employ a
wider range of physical mechanisms than at any other time in an organism's life. This book …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca2+
concentration ([Ca2+] c) depends on at least four efficient regulatory systems: 1) …

The plasma membrane is a two-dimensional compartment that relays most biological
signals sent or received by a cell. Signalling involves membrane receptors and their …

Complex biological environments, such as the cell cytoplasm or the mucus lining the
airways of the lungs, can pose significant barriers to efficient therapeutic drug and gene …

Evanescent wave microscopy, also termed total internal reflection fluorescence microscopy
(TIR-FM), has shed new light on important cellular processes taking place near the plasma …

In electron micrographs, many secretory and synaptic vesicles are found 'docked'at the
target membrane, but it is unclear why and how. It is generally assumed that docking is a …

Total internal reflection fluorescence microscopy (TIRFM), also known as evanescent wave
microscopy, is used in a wide range of applications, particularly to view single molecules …

Insulin-stimulated GLUT4 translocation is central to glucose homeostasis. Functional assays
to distinguish individual steps in the GLUT4 translocation process are lacking, thus limiting …