In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Atherosclerosis is closely associated with disturbed flow characterized by low and oscillatory
shear stress, but studies directly linking disturbed flow to atherogenesis is lacking. The major …

Background Shed membrane microparticles circulate in the peripheral blood of nonischemic
(NI) patients and patients with myocardial infarction (MI). We investigated whether or not …

Objective To investigate the beneficial role of prebiotics on endothelial dysfunction, an early
key marker of cardiovascular diseases, in an original mouse model linking steatosis and …

Aims: Increased oxidative stress and vascular inflammation are implicated in increased
cardiovascular disease (CVD) incidence with age. We and others demonstrated that NOX1/2 …

▪ Abstract Nitric oxide (NO) is synthesized from L-arginine by NO synthase (NOS). As an
endothelium-derived relaxing factor, a mediator of immune responses, a neurotransmitter, a …

Endothelial dysfunction is a key triggering event in atherosclerosis. Following the entry of
lipoproteins into the vessel wall, their rapid modification results in the generation of …

In recent years, oxidative stress has been implicated in a variety of degenerative processes,
diseases, and syndromes. Some of these include atherosclerosis, myocardial infarction …

Objective—Inflammation-driven endothelial dysfunction initiates and contributes to the
progression of atherosclerosis, and MPO (myeloperoxidase) has been implicated as a …