The impact of obesity on the musculoskeletal system

A Anandacoomarasamy, I Caterson… - International journal of …, 2008 - nature.com
Obesity is associated with a range of disabling musculoskeletal conditions in adults. As the
prevalence of obesity increases, the societal burden of these chronic musculosketelal …

Osteoarthritis: an overview of the disease and its treatment strategies

P Sarzi-Puttini, MA Cimmino, R Scarpa… - Seminars in arthritis and …, 2005 - Elsevier
Osteoarthritis (OA) is currently defined by the American College of Rheumatology as a
“heterogeneous group of conditions that leads to joint symptoms and signs which are …

Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo …

JP Lugo, ZM Saiyed, NE Lane - Nutrition journal, 2015 - Springer
Background Undenatured type II collagen (UC-II) is a nutritional supplement derived from
chicken sternum cartilage. The purpose of this study was to evaluate the efficacy and …

[HTML][HTML] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

VB Kraus, B Burnett, J Coindreau, S Cottrell… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …

Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis

D Schiphof, M Boers… - Annals of the rheumatic …, 2008 - ard.bmj.com
Objective: Correct application of the Kellgren and Lawrence (K&L) classification system is
difficult due to inexact wording of the descriptors. We summarised different descriptions and …

Sex-dependent variation in cartilage adaptation: from degeneration to regeneration

J Patel, S Chen, T Katzmeyer, YA Pei, M Pei - Biology of sex Differences, 2023 - Springer
Despite acknowledgement in the scientific community of sex-based differences in cartilage
biology, the implications for study design remain unclear, with many studies continuing to …

Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: a novel diagnostic and prognostic biomarker

P Verma, K Dalal - Journal of Orthopaedic Research, 2013 - Wiley Online Library
ABSTRACT A case–control study was conducted to estimate the association of cartilage
oligomeric matrix protein (COMP) with knee osteoarthritis (OA) and to examine the potential …

Cartilage oligomeric matrix protein (COMP): a biomarker of arthritis

S Tseng, AH Reddi, PE Di Cesare - Biomarker insights, 2009 - journals.sagepub.com
Arthritis is a chronic disease with a significant impact on the population. It damages the
cartilage, synovium, and bone of the joints causing pain, impairment, and disability in …

[HTML][HTML] Cartilage oligomeric matrix protein, C-terminal cross-linking telopeptide of type II collagen, and matrix metalloproteinase-3 as biomarkers for knee and hip …

HQ Hao, JF Zhang, QQ He, Z Wang - Osteoarthritis and cartilage, 2019 - Elsevier
Objective This study was design to examine the diagnostic performance of cartilage
oligomeric matrix protein (COMP), C-terminal cross-linking telopeptide of type II collagen …

Knee structural alteration and BMI: a cross‐sectional study

C Ding, F Cicuttini, F Scott, H Cooley… - Obesity …, 2005 - Wiley Online Library
Objective: To describe the associations among BMI, knee cartilage morphology, and bone
size in adults. Research Methods and Procedures: A cross‐sectional convenience sample of …