Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Bacterial sepsis is a major cause of fatality worldwide. Sepsis is a multi-step process that
involves an uncontrolled inflammatory response by the host cells that may result in multi …

The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …

Anthrax is caused by the spore-forming, gram-positive bacterium Bacillus anthracis. The
bacterium's major virulence factors are (a) the anthrax toxins and (b) an antiphagocytic …

Members of the Bacillus cereus group of organisms include Bacillus cereus, Bacillus
anthracis and Bacillus thuringiensis. Collectively, these organisms represent microbes of …

Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-
bearing mammalian cells or in solution, yielding a series of toxic complexes. Two of the …

Caspase-1 cleaves the inactive IL-1β and IL-18 precursors into active inflammatory
cytokines. In Salmonella-infected macrophages, caspase-1 also mediates a pathway of …

▪ Abstract Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary
combinations to form toxic complexes at the surface of mammalian cells. One of these …

Enzyme responsive materials (ERMs) are a class of stimuli responsive materials with broad
application potential in biological settings. This review highlights current and potential future …

Certain pathogenic species of Bacillus and Clostridium have developed unique methods for
intoxicating cells that employ the classic enzymatic “AB” paradigm for protein toxins. The …