Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Alzheimer's disease (AD) is the most prevalent cause of dementia and is pathologically
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …

Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …

Traumatic brain injury (TBI) is one the most common human afflictions, contributing to long-
term disability in survivors. Emerging data indicate that functional improvement or …

The societal burden of Alzheimer's disease (AD) is staggering, with current estimates
suggesting that 50 million people world-wide have AD. Identification of new therapeutic …

Abstract Trimethylamine-N-oxide (TMAO), a metabolite of gut microbiota, has been
implicated in the pathogenesis of Alzheimer's disease (AD). However, the mechanisms by …

Alzheimer's disease is associated with multiple risk factors and is the most common type of
dementia. Trimethylamine‐N‐oxide (TMAO), a gut microbiota metabolite derived from …

Alzheimer's disease (AD) is characterised by pathologic cerebrovascular remodelling.
Whether this occurs already before disease onset, as may be indicated by early Braak tau …

Arterial stiffness is emerging as an important risk marker for poor brain aging and dementia
through its associations with cerebral small vessel disease, stroke, β-amyloid deposition …

Most disease-gene association methods do not account for gene-gene interactions, even
though these play a crucial role in complex, polygenic diseases like Alzheimer's disease …