Ferroptosis in cancer and cancer immunotherapy

L Zhao, X Zhou, F Xie, L Zhang, H Yan… - Cancer …, 2022 - Wiley Online Library
The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

Iron metabolism in ferroptosis

X Chen, C Yu, R Kang, D Tang - Frontiers in cell and developmental …, 2020 - frontiersin.org
Ferroptosis is a form of regulated cell death that is characterized by iron-dependent
oxidative damage and subsequent plasma membrane ruptures and the release of damage …

A guide to plasma membrane solute carrier proteins

MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

[HTML][HTML] Iron homeostasis and oxidative stress: An intimate relationship

D Galaris, A Barbouti, K Pantopoulos - Biochimica et Biophysica Acta (BBA) …, 2019 - Elsevier
Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …

Regulatory pathways and drugs associated with ferroptosis in tumors

D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo… - Cell Death & …, 2022 - nature.com
Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …

Altered iron metabolism and impact in cancer biology, metastasis, and immunology

RAM Brown, KL Richardson, TD Kabir, D Trinder… - Frontiers in …, 2020 - frontiersin.org
Iron is an essential nutrient that plays a complex role in cancer biology. Iron metabolism
must be tightly controlled within cells. Whilst fundamental to many cellular processes and …

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

[HTML][HTML] Ferroptosis in life: To be or not to be

L Xu, Y Liu, X Chen, H Zhong, Y Wang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …

[HTML][HTML] Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor

H Yu, C Yang, L Jian, S Guo, R Chen… - Oncology …, 2019 - spandidos-publications.com
The aim of the present study was to clarify the activation of ferroptosis in different breast
cancer cells by sulfasalazine (SAS) and to explore the relationship between the estrogen …