Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …

Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …