Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Amino assets: how amino acids support immunity

B Kelly, EL Pearce - Cell metabolism, 2020 - cell.com
Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Glutamine: metabolism and immune function, supplementation and clinical translation

V Cruzat, M Macedo Rogero, K Noel Keane, R Curi… - Nutrients, 2018 - mdpi.com
Glutamine is the most abundant and versatile amino acid in the body. In health and disease,
the rate of glutamine consumption by immune cells is similar or greater than glucose. For …

Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites

S Russo, M Kwiatkowski, N Govorukhina… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics

P Puchalska, PA Crawford - Cell metabolism, 2017 - cell.com
Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

A guide to immunometabolism for immunologists

LAJ O'Neill, RJ Kishton, J Rathmell - Nature reviews immunology, 2016 - nature.com
In recent years a substantial number of findings have been made in the area of
immunometabolism, by which we mean the changes in intracellular metabolic pathways in …

A role for the Krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation

NC Williams, LAJ O'Neill - Frontiers in immunology, 2018 - frontiersin.org
Metabolism in immune cells is no longer thought of as merely a process for adenosine
triphosphate (ATP) production, biosynthesis, and catabolism. The reprogramming of …

The immune system's role in sepsis progression, resolution, and long‐term outcome

MJ Delano, PA Ward - Immunological reviews, 2016 - Wiley Online Library
Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

Immunometabolism governs dendritic cell and macrophage function

LAJ O'Neill, EJ Pearce - Journal of Experimental Medicine, 2016 - rupress.org
Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive …

Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages

A Marrocco, LA Ortiz - Frontiers in immunology, 2022 - frontiersin.org
In the lungs, macrophages constitute the first line of defense against pathogens and foreign
bodies and play a fundamental role in maintaining tissue homeostasis. Activated …