Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

1 ESGE recommends cold snare polypectomy (CSP) as the preferred technique for removal
of diminutive polyps (size≤ 5 mm). This technique has high rates of complete resection …

The concept of a CpG island methylator phenotype (CIMP) was first introduced by Toyota
and Issa to describe a subset of colorectal cancers (CRCs) with concurrent hypermethylation …

Several types of nonconventional dysplasia have been recently described in inflammatory
bowel disease (IBD). However, strict morphologic criteria are lacking, and their …

Sessile serrated adenoma/polyps (SSA/Ps) are believed to be the major precursor of
serrated pathway-derived colorectal carcinomas. To better characterize the process of …

Colorectal cancer (CRC) is common and at least 80% of cases are sporadic, without any
significant family history. Prognostication and treatment have been relatively empirical for …

Objective To provide an overview of the pathology and molecular pathogenesis of traditional
serrated adenomas (TSA). Design Describe the morphology and molecules that play a role …

Colorectal cancer (CRC) is the fourth most common cause of cancer-related death and the
third most common cancer in the world. Depending on the origin of the mutation, colorectal …

Two breakthrough techniques that have totally revolutionized biology in last 1 decade are
the discovery of genome editing tools and growing the stem cells/primary tissue explants in …

RNF43 is an E3 ligase that suppresses the Wnt/β-catenin signaling pathway and is
frequently mutated in microsatellite-unstable colorectal carcinoma. To investigate the …