DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

In a majority of pathophysiological settings, cell death is not accidental—it is controlled by a
complex molecular apparatus. Such a system operates like a computer: it receives several …

ATM, the protein kinase mutated in the rare human disease ataxia telangiectasia (AT), has
been the focus of intense scrutiny over the past two decades. Initially this was because of the …

Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases
(CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link …

Unscheduled increases in ploidy underlie defects in tissue function, premature aging, and
malignancy. A concomitant event to polyploidization is the amplification of centrosomes, the …

Molecular alterations of the Ataxia-telangiectasia (AT) gene are frequently detected in breast
cancer (BC), with an incidence ranging up to 40%. The mutated form, the Ataxia …

The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the
appropriate cellular programs to maintain genome integrity. This includes the coordination of …