Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

Polygenic risk scores (PRSs), which often aggregate results from genome-wide association
studies, can bridge the gap between initial discovery efforts and clinical applications for the …

Early detection of breast cancer through screening reduces breast cancer mortality. The
benefits of screening must also be considered within the context of potential harms (eg, false …

Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-
related lung cancers continue to account for the majority of diagnoses, smoking rates have …

Background BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier
Estimation Algorithm) for breast cancer and the epithelial tubo-ovarian cancer (EOC) models …

Purpose Polygenic risk influences susceptibility to cancer. We assessed whether polygenic
risk scores could be used in conjunction with other predictors of future disease status in cost …

Thirty-eight states and the District of Columbia (DC) have dense breast notification laws that
mandate varying levels of patient notification about breast density after a mammogram, and …

Background: The multifactorial risk prediction model BOADICEA enables identification of
women at higher or lower risk of developing breast cancer. BOADICEA models genetic …

Background Common low-risk variants are presently not used to guide clinical management
of familial breast cancer (BC). We explored the additive impact of a 313-variant-based …

PURPOSE Screening and prevention decisions for women at increased risk of developing
breast cancer depend on genetic and clinical factors to estimate risk and select appropriate …