Marine sponges are productive sources of bioactive secondary metabolites with over 200
new compounds isolated each year, contributing 23% of approved marine drugs so far. This …

Covering: up to 2014 Various marine natural products that target cytoskeletal proteins have
been discovered. A few of these compounds have recently been shown to induce or inhibit …

Intracellular cargos are often membrane-enclosed and transported by microtubule-based
motors in the presence of microtubule-associated proteins (MAPs). Whereas increasing …

Actin and microtubules play essential roles in aberrant cell processes that define and
converge in cancer including: signaling, morphology, motility, and division. Actin and …

Cytoplasmic dynein and kinesin are both microtubule-based molecular motors but are
structurally and evolutionarily unrelated. Under standard conditions, both move with …

Covering: 2014–2019 We review recent progress on natural products that target cytoskeletal
components, including microtubules, actin, intermediate filaments, and septins and highlight …

The human genome encodes 45 kinesin motor proteins that drive cell division, cell motility,
intracellular trafficking and ciliary function. Determining the cellular function of each kinesin …

Kinesins are a group of motor proteins in charge of several crucial functions in the cell.
These proteins often bind to microtubules and perform their functions using the energy …

The majority of natural products utilized to treat a diverse array of human conditions and
diseases are derived from terrestrial sources. In recent years, marine ecosystems have …

Intracellular transport of cargos along microtubules is often complicated by the topology of
the underlying filament network. The fundamental building blocks for this complex …