As with most medical and pharmacologic interventions, mechanical ventilation must be
titrated within a therapeutic window, providing the required lifesustaining support while …

Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give
rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory …

Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at
approximately 39%. One of the only treatments is supportive: mechanical ventilation …

Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

Purpose Open lung strategy during ARDS aims to decrease the ventilator-induced lung
injury by minimizing the atelectrauma and stress/strain maldistribution. We aim to assess …

The dynamics of respiratory airflows and the associated transport mechanisms of inhaled
aerosols characteristic of the deep regions of the lungs are of broad interest in assessing …

Purpose Nasal irrigation or nebulizing aerosol of isotonic or hypertonic saline is a traditional
method for respiratory or nasal care. A recent small study in outpatients with COVID-19 …

The positive end-expiratory pressure (PEEP), since its introduction in the treatment of acute
respiratory failure, up to the 1980s was uniquely aimed to provide a viable oxygenation …

Epithelial cells of the lung are located at the interface between the environment and the
organism and serve many important functions including barrier protection, fluid balance …

Airways of the peripheral lung are prone to closure at low lung volumes. Deficiency or
dysfunction of pulmonary surfactant during various lung diseases compounds this event by …