Cells change their metabolism in response to internal and external conditions by regulating
the trans-omic network, which is a global biochemical network with multiple omic layers …

Systemic metabolic homeostasis is regulated by inter-organ metabolic cycles involving
multiple organs. Obesity impairs inter-organ metabolic cycles, resulting in metabolic …

Background: The sensitivity and specificity of current breath biomarkers are often
inadequate for effective cancer screening, particularly in colorectal cancer (CRC). While a …

Currently, the bottom-up approach, in which proteins are digested by enzymes such as
trypsin prior to mass spectrometry, is the mainstream approach in mass spectrometer-based …

Hepatic glucose metabolism serves dual purposes: maintaining glucose homeostasis and
converting glucose into energy sources; however, the underlying mechanisms are unclear …

Each tissue has a dominant set of functional proteins required to mediate tissue-specific
functions. Epigenetic modifications, transcription, and translational efficiency control tissue …

Metabolic syndrome (MetS) is a global health problem, and EPA/DHA-enriched
phospholipids (EPA/DHA-PLs) have been found to have positive effects on MetS …

Glucose homeostasis is maintained by modulation of metabolic flux. Enzymes and
metabolites regulate the involved metabolic pathways. Dysregulation of glucose …

An effective combination of multi-omic datasets can enhance our understanding of complex
biological phenomena. To build a context-dependent network with multiple omic layers, ie, a …

Background Leptin plays a critical role in the regulation of metabolic homeostasis. However,
the molecular mechanism and cross talks between leptin and metabolic pathways leading to …