Despite their roles in intercellular communications, the different populations of extracellular
vesicles (EVs) and their secretion mechanisms are not fully characterized: how and to what …

Translating data to knowledge and actionable insights is the Holy Grail for many scientific
fields, including biology. The unprecedented massive and heterogeneous data have created …

Extracellular vesicles (EVs) have become the focus of rising interest because of their
numerous functions in physiology and pathology. Cells release heterogeneous vesicles of …

How to process and analyze MS data to quantify and statistically compare protein
abundances in bottom-up proteomics has been an open debate for nearly fifteen years. Two …

Inflammation is a complex physiological process triggered in response to harmful stimuli. It
involves cells of the immune system capable of clearing sources of injury and damaged …

Extracellular vesicles (EVs) are released by most cell types but providing evidence for their
physiological relevance remains challenging due to a lack of appropriate model organisms …

Bacterial outer membrane vesicle (OMV)-mediated delivery of proteins to host cells is an
important mechanism of host-pathogen communication. Emerging evidence suggests that …

During development, the precise relationships between transcription and chromatin
modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm …

Brain postnatal development is characterized by critical periods of experience-dependent
remodeling of neuronal circuits. Failure to end these periods results in neurodevelopmental …

Xist represents a paradigm for the function of long non-coding RNA in epigenetic regulation,
although how it mediates X-chromosome inactivation (XCI) remains largely unexplained …