The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

The ability of the adaptive immune system to form memory is key to providing protection
against secondary infections. Resident memory T cells (TRM) are specialized T cell …

In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …

Coccidioidomycosis is an endemic fungal infection that is reported in up to 20,000 persons
per year and has an economic impact close to $1.5 billion. Natural infection virtually always …

Candida spp. are the fourth leading cause of bloodstream infections in hospitalized patients
and the most common cause of invasive fungal infection. No vaccine against Candida spp …

Fungal disease poses a growing threat to public health that our current antifungal therapies
are not well equipped to meet. As the population of immunocompromised hosts expands …

Researchers who aim to globally analyze the gastrointestinal immune system via flow
cytometry have many protocol options to choose from, with specifics generally tied to gut …

Fungi are an integral part of the mammalian microbiota colonizing most if not all mucosal
surfaces and the skin. Maintaining stable colonization on these surfaces is critical for …

The development of effective vaccines against fungal infections requires the induction of
protective, pathogen-specific cell-mediated immune responses. Here, we asked whether …

Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To
distinguish features of memory cells that confer protective immunity, we used single cell …