Proteomic analysis of cells, tissues and body fluids has generated valuable insights into the
complex processes influencing human biology. Proteins represent intermediate phenotypes …

The study of proteins circulating in blood offers tremendous opportunities to diagnose,
stratify, or possibly prevent diseases. With recent technological advances and the urgent …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …

Understanding the dynamics of the human proteome is crucial for developing biomarkers to
be used as measurable indicators for disease severity and progression, patient stratification …

Many proteins are present at low concentrations in biological samples, and therefore,
techniques for ultrasensitive protein detection are necessary. To overcome challenges with …

Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer's
disease and its diverse pathological processes are urgently needed. Here, we undertook an …

For a complete understanding of a system's processes and each protein's role in health and
disease, it is essential to study protein expression with a spatial resolution, as the exact …

The blood proteome holds great promise for precision medicine but poses substantial
challenges due to the low abundance of most plasma proteins and the vast dynamic range …

Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …