The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic

AH Tan, SY Lim, AE Lang - Nature Reviews Neurology, 2022 - nature.com
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

[HTML][HTML] Helicobacter pylori Infection: Current Status and Future Prospects on Diagnostic, Therapeutic and Control Challenges

A Elbehiry, E Marzouk, M Aldubaib, A Abalkhail… - Antibiotics, 2023 - mdpi.com
Helicobacter pylori (H. pylori) infection, which affects approximately half of the world's
population, remains a serious public health problem. As H. pylori infection leads to a number …

Microbiota-brain-gut axis and neurodegenerative diseases

EMM Quigley - Current neurology and neuroscience reports, 2017 - Springer
Abstract Purpose of Review The purposes of this review were as follows: first, to provide an
overview of the gut microbiota and its interactions with the gut and the central nervous …

Colonic bacterial composition in Parkinson's disease

A Keshavarzian, SJ Green, PA Engen… - Movement …, 2015 - Wiley Online Library
Abstract Introduction We showed that Parkinson's disease (PD) patients have alpha‐
synuclein (α‐Syn) aggregation in their colon with evidence of colonic inflammation. If PD …

The human microbiome in disease and pathology

J Manos - Apmis, 2022 - Wiley Online Library
This narrative review seeks to examine the relationships between bacterial microbiomes
and infectious disease. This is achieved by detailing how different human host microbiomes …

[HTML][HTML] Autonomic dysfunction in Parkinson's disease: Implications for pathophysiology, diagnosis, and treatment

Z Chen, G Li, J Liu - Neurobiology of disease, 2020 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease with a 200 year-long research
history. Our understanding about its clinical phenotype and pathogenesis remains limited …

Gut microbial ecosystem in Parkinson disease: new clinicobiological insights from multi‐omics

AH Tan, CW Chong, SY Lim, IKS Yap… - Annals of …, 2021 - Wiley Online Library
Objective Gut microbiome alterations in Parkinson disease (PD) have been reported
repeatedly, but their functional relevance remains unclear. Fecal metabolomics, which …

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

L Klingelhoefer, H Reichmann - Nature Reviews Neurology, 2015 - nature.com
Parkinson disease (PD) follows a defined clinical pattern, and a range of nonmotor
symptoms precede the motor phase. The predominant early nonmotor manifestations are …

[HTML][HTML] Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
Abstract Parkinson's disease (PD), the second most common age-associated
neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and …

[HTML][HTML] Helicobacter pylori and extragastric diseases: A review

AG Gravina, RM Zagari, C De Musis… - World journal of …, 2018 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) infection is very common and affects approximately half of the
world population. It causes gastric diseases, but some authors have reported an association …