New advances in cross-linking mass spectrometry toward structural systems biology
Elucidating protein–protein interaction (PPI) networks and their structural features within
cells is central to understanding fundamental biology and associations of cell phenotypes …
cells is central to understanding fundamental biology and associations of cell phenotypes …
Residue selective crosslinking of proteins through photoactivatable or proximity-enabled reactivity
Photo-and chemical crosslinking of proteins have offered various avenues for studying
protein structure and protein interactions with biomolecules. Conventional photoactivatable …
protein structure and protein interactions with biomolecules. Conventional photoactivatable …
Dissecting diazirine photo-reaction mechanism for protein residue-specific cross-linking and distance mapping
Y Jiang, X Zhang, H Nie, J Fan, S Di, H Fu… - Nature …, 2024 - nature.com
While photo-cross-linking (PXL) with alkyl diazirines can provide stringent distance restraints
and offer insights into protein structures, unambiguous identification of cross-linked residues …
and offer insights into protein structures, unambiguous identification of cross-linked residues …
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
The exploration of protein structure and function stands at the forefront of life science and
represents an ever‐expanding focus in the development of proteomics. As mass …
represents an ever‐expanding focus in the development of proteomics. As mass …
ComMap: a software to perform large-scale structure-based mapping for cross-linking mass spectrometry
Motivation Chemical cross-linking combined with mass spectrometry (CXMS) is now a well-
established method for profiling existing protein–protein interactions (PPIs) with partially …
established method for profiling existing protein–protein interactions (PPIs) with partially …