Tryptophan synthase (TrpS) has emerged as a paragon of noncanonical amino acid (ncAA)
synthesis and is an ideal biocatalyst for synthetic and biological applications. TrpS catalyzes …

Melatonin is a natural hormone primarily released by the pineal gland that regulates the
sleep-wake cycles. The diverse biological applications of melatonin, together with the need …

Catalytic asymmetric conversion of carbon dioxide (CO2) into valuable chiral compounds is
one of the most challenging research topics in the field of CO2 utilization. Although great …

Nickel-catalyzed oxidative C (sp2)–H/C (sp3)–H coupling of indoles with toluene derivatives
is successfully achieved in the presence of 2-iodobutane as the oxidant. This method allows …

We report the first total syntheses of (+)-haplocidine and its N1-amide congener (+)-
haplocine. Our concise synthesis of these alkaloids required the development of a late-stage …

The N‐iodosuccinimide‐mediated spirocyclization of tryptamine‐derived isocyanides to
generate spiroindolenines is reported. The products contain both an imine and an imidoyl …

We report an efficient and highly stereoselective strategy for the synthesis of Aspidosperma
alkaloids based on the transannular cyclization of a chiral lactam precursor. Three new …

Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-
activated prodrugs, designed to selectively target hypoxic cells while sparing normal tissue …

Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected
β-Amino Alcohols as Alkylating Agents | The Journal of Organic Chemistry ACS ACS Publications …

A first and short total synthesis of the marine sponge 2, 3′-bis (indolyl) ethylamine (2, 3′-
BIEA) alkaloid (±)-gelliusine E was performed in both a three-step divergent approach and a …