Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19

F De Virgiliis, S Di Giovanni - Nature Reviews Neurology, 2020 - nature.com
COVID-19 is an infectious disease caused by the coronavirus SARS-CoV-2, which was first
reported in Wuhan, China, in December 2019 and has caused a global pandemic. Acute …

Mechanisms underlying the neuronal-based symptoms of allergy

BJ Undem, T Taylor-Clark - Journal of Allergy and Clinical Immunology, 2014 - Elsevier
Persons with allergies present with symptoms that often are the result of alterations in the
nervous system. Neuronally based symptoms depend on the organ in which the allergic …

Eosinophil extracellular traps drive asthma progression through neuro-immune signals

Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li… - Nature Cell …, 2021 - nature.com
Eosinophilic inflammation is a feature of allergic asthma. Despite mounting evidence
showing that chromatin filaments released from neutrophils mediate various diseases, the …

Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

AC Bohrer, E Castro, Z Hu, ATL Queiroz… - Journal of Experimental …, 2021 - rupress.org
Host resistance to Mycobacterium tuberculos is (Mtb) infection requires the activities of
multiple leukocyte subsets, yet the roles of the different innate effector cells during …

Eosinophils increase airway sensory nerve density in mice and in human asthma

MG Drake, GD Scott, ED Blum, KM Lebold… - Science translational …, 2018 - science.org
In asthma, airway nerve dysfunction leads to excessive bronchoconstriction and cough. It is
well established that eosinophils alter nerve function and that airway eosinophilia is present …

Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

DB Jacoby, GJ Gleich, AD Fryer - The Journal of clinical …, 1993 - Am Soc Clin Investig
The effect of human eosinophil major basic protein (MBP) as well as other eosinophil
proteins, on binding of [3H] N-methyl-scopolamine ([3H] NMS: 1 x 10 (-10) M) to muscarinic …

Muscarinic receptors and control of airway smooth muscle

AD Fryer, DB Jacoby - American journal of respiratory and critical …, 1998 - atsjournals.org
Contraction of airway smooth muscle is mediated by M3 muscarinic receptors on the airway
smooth muscle. However, there is no evidence suggesting that hyperresponsiveness results …

Muscarinic acetylcholine receptors and airway diseases

FR Coulson, AD Fryer - Pharmacology & therapeutics, 2003 - Elsevier
Parasympathetic nerves provide the dominant autonomic innervation of the airways.
Release of acetylcholine from parasympathetic nerves activates postjunctional muscarinic …

The pathogenesis of chronic obstructivepulmonary disease of horses

NE Robinson, FJ Derksen, MA Olszewski… - British Veterinary …, 1996 - Elsevier
Present evidence suggests that chronic obstructive pulmonary disease (COPD) of horses is
a delayed hypersensitivity response to inhaled antigens, particularly the thermophilic …

Eosinophil and airway nerve interactions in asthma

MG Drake, KM Lebold, QR Roth-Carter… - Journal of leukocyte …, 2018 - academic.oup.com
Airway eosinophils are increased in asthma and are especially abundant around airway
nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where …