Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos - Pharmacological reviews, 2017 - ASPET
Over the last decade, hydrogen sulfide (H2S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Hydrogen sulfide in physiology and diseases of the digestive tract

SB Singh, HC Lin - Microorganisms, 2015 - mdpi.com
Hydrogen sulfide (H2S) is a Janus-faced molecule. On one hand, several toxic functions
have been attributed to H2S and exposure to high levels of this gas is extremely hazardous …

Development of Spleen Targeting H2S Donor Loaded Liposome for the Effective Systemic Immunomodulation and Treatment of Inflammatory Bowel Disease

C Oh, W Lee, J Park, J Choi, S Lee, S Li, HN Jung… - ACS …, 2023 - ACS Publications
Nanoparticles are primarily taken up by immune cells after systemic administration. Thus,
they are considered an ideal drug delivery vehicle for immunomodulation. Because the …

Hydrogen sulfide and cell signaling: team player or referee?

JT Hancock, M Whiteman - Plant Physiology and Biochemistry, 2014 - Elsevier
Hydrogen sulfide (H 2 S) has been postulated to be the third gasotransmitter, and along with
other reactive compounds such as reactive oxygen species (ROS) and nitric oxide (NO) it is …

Hydrogen sulfide in pharmacology and medicine–an update

J Bełtowski - Pharmacological Reports, 2015 - Elsevier
Hydrogen sulfide (H 2 S) is the endogenously produced gasotransmitter involved in the
regulation of nervous system, cardiovascular functions, inflammatory response …