Application of radiosensitizers in cancer radiotherapy

L Gong, Y Zhang, C Liu, M Zhang… - International journal of …, 2021 - Taylor & Francis
Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells
and shrink tumors. Although great success has been achieved on radiotherapy, there is still …

Cancer radiosensitizers

H Wang, X Mu, H He, XD Zhang - Trends in pharmacological sciences, 2018 - cell.com
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a
large challenge to enhance radiation damage to tumor tissue and reduce side effects to …

Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

CW Schultz, R Preet, T Dhir, DA Dixon… - Wiley Interdisciplinary …, 2020 - Wiley Online Library
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …

Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

[HTML][HTML] Redox regulation in tumor cell epithelial–mesenchymal transition: Molecular basis and therapeutic strategy

J Jiang, K Wang, Y Chen, H Chen, EC Nice… - … and Targeted Therapy, 2017 - nature.com
Epithelial–mesenchymal transition (EMT) is recognized as a driving force of cancer cell
metastasis and drug resistance, two leading causes of cancer recurrence and cancer …

[HTML][HTML] RNA binding proteins (RBPs) and their role in DNA damage and radiation response in cancer

M Mehta, R Raguraman, R Ramesh… - Advanced drug delivery …, 2022 - Elsevier
Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment

N Amreddy, A Babu, J Panneerselvam… - … , Biology and Medicine, 2018 - Elsevier
Co-administration of functionally distinct anti-cancer agents has emerged as an efficient
strategy in lung cancer treatment. However, a specially designed drug delivery system is …

Posttranscriptional upregulation of IDH1 by HuR establishes a powerful survival phenotype in pancreatic cancer cells

M Zarei, S Lal, SJ Parker, A Nevler, A Vaziri-Gohar… - Cancer research, 2017 - AACR
Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived
microenvironment. Here we illustrate how such conditions promote chemotherapy …

[HTML][HTML] Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy

A Babu, N Amreddy, R Muralidharan, G Pathuri… - Scientific reports, 2017 - nature.com
In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified
polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin αvβ3 …

[HTML][HTML] RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC

SJ Kim, JS Ju, MH Kang, JE Won, YH Kim… - Theranostics, 2020 - ncbi.nlm.nih.gov
Breast cancer (BC) is one of the most common cancers in women. TNBC (Triple-negative
breast cancer) has limited treatment options and still lacks viable molecular targets, leading …