Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update

R Siracusa, RD Paola, S Cuzzocrea… - International journal of …, 2021 - mdpi.com
Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

Neuroinflammation and central sensitization in chronic and widespread pain

RR Ji, A Nackley, Y Huh, N Terrando… - …, 2018 - pmc.ncbi.nlm.nih.gov
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …

Passive transfer of fibromyalgia symptoms from patients to mice

A Goebel, E Krock, C Gentry, MR Israel… - The Journal of …, 2021 - Am Soc Clin Investig
Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and
patients typically experience fatigue and emotional distress. The etiology and …

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

M Matsuda, Y Huh, RR Ji - Journal of anesthesia, 2019 - Springer
Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …

Pain regulation by non-neuronal cells and inflammation

RR Ji, A Chamessian, YQ Zhang - Science, 2016 - science.org
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …

An inflammation-centric view of neurological disease: beyond the neuron

SD Skaper, L Facci, M Zusso, P Giusti - Frontiers in cellular …, 2018 - frontiersin.org
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Neurobiology of fibromyalgia and chronic widespread pain

KA Sluka, DJ Clauw - Neuroscience, 2016 - Elsevier
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …

Emerging targets in neuroinflammation-driven chronic pain

RR Ji, ZZ Xu, YJ Gao - Nature reviews Drug discovery, 2014 - nature.com
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Fibromyalgia

W Häuser, J Ablin, MA Fitzcharles, G Littlejohn… - Nature reviews Disease …, 2015 - nature.com
Fibromyalgia is a common illness characterized by chronic widespread pain, sleep
problems (including unrefreshing sleep), physical exhaustion and cognitive difficulties. The …

The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes

AJ Terkelsen, P Karlsson, G Lauria, R Freeman… - The lancet …, 2017 - thelancet.com
Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …