Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update
R Siracusa, RD Paola, S Cuzzocrea… - International journal of …, 2021 - mdpi.com
Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …
Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …
plasticity and increased neuronal responsiveness in central pain pathways after painful …
Passive transfer of fibromyalgia symptoms from patients to mice
A Goebel, E Krock, C Gentry, MR Israel… - The Journal of …, 2021 - Am Soc Clin Investig
Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and
patients typically experience fatigue and emotional distress. The etiology and …
patients typically experience fatigue and emotional distress. The etiology and …
Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain
Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …
Pain regulation by non-neuronal cells and inflammation
RR Ji, A Chamessian, YQ Zhang - Science, 2016 - science.org
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis,
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …
nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a …
An inflammation-centric view of neurological disease: beyond the neuron
Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …
Neurobiology of fibromyalgia and chronic widespread pain
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …
alternative cause can be identified. The underlying mechanisms, in both human and animal …
Emerging targets in neuroinflammation-driven chronic pain
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …
and have limited success in controlling disease progression. Accumulating evidence …
Fibromyalgia
W Häuser, J Ablin, MA Fitzcharles, G Littlejohn… - Nature reviews Disease …, 2015 - nature.com
Fibromyalgia is a common illness characterized by chronic widespread pain, sleep
problems (including unrefreshing sleep), physical exhaustion and cognitive difficulties. The …
problems (including unrefreshing sleep), physical exhaustion and cognitive difficulties. The …
The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes
Small fibre neuropathies are a heterogeneous group of disorders affecting thinly myelinated
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …
Aδ-fibres and unmyelinated C-fibres. Although multiple causes of small nerve fibre …