The multi-factorial nature of clinical multidrug resistance in cancer
Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …
Multidrug resistance proteins (MRPs): Structure, function and the overcoming of cancer multidrug resistance
ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …
and mechanistically distinct substrates against steep concentration gradients. Among the …
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade
ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
Barriers to drug delivery in solid tumors
SK Sriraman, B Aryasomayajula, VP Torchilin - Tissue barriers, 2014 - Taylor & Francis
Over the last decade, significant progress has been made in the field of drug delivery. The
advent of engineered nanoparticles has allowed us to circumvent the initial limitations to …
advent of engineered nanoparticles has allowed us to circumvent the initial limitations to …
Bcl-2 antiapoptotic family proteins and chemoresistance in cancer
Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …
[HTML][HTML] Multidrug resistance proteins (MRPs) and cancer therapy
The ATP-binding cassette (ABC) transporters are members of a protein superfamily that are
known to translocate various substrates across membranes, including metabolic products …
known to translocate various substrates across membranes, including metabolic products …
The role of ABC transporters in ovarian cancer progression and chemoresistance
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …
course of the disease. A well-established cause of chemoresistance involves the family of …
The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond
Abstract Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC)
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …
transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001 …
[HTML][HTML] Tetrazole and oxadiazole derivatives as bioisosteres of tariquidar and elacridar: New potent P-gp modulators acting as MDR reversers
L Braconi, S Dei, M Contino, C Riganti… - European Journal of …, 2023 - Elsevier
Abstract New 2, 5-and 1, 5-disubstituted tetrazoles, and 2, 5-disubstituted-1, 3, 4-
oxadiazoles were synthesized as tariquidar and elacridar derivatives and studied as …
oxadiazoles were synthesized as tariquidar and elacridar derivatives and studied as …
[HTML][HTML] HES1 promotes colorectal cancer cell resistance to 5-Fu by inducing of EMT and ABC transporter proteins
L Sun, J Ke, Z He, Z Chen, Q Huang, W Ai… - Journal of …, 2017 - ncbi.nlm.nih.gov
Abstract Background and Aim: Hairy enhancer of split-1 (HES1) is a downstream
transcriptional factor of Notch signaling pathway, which was found to be related to …
transcriptional factor of Notch signaling pathway, which was found to be related to …