The development of suitable biomaterials with the ability to improve repair and regeneration
of human tissues is continuously in progress, and mechanical properties of biomaterials play …

Fibroblasts produce and turn over collagenous extracellular matrix as part of the normal
adaptive response to increased mechanical load in the heart, eg during prolonged exercise …

Considerable progress has been made in recent years toward elucidating a conceptual
framework that integrates the dynamic functional structure, mechanical properties, and …

The hallmarks of calcific aortic valve disease (CAVD) are the significant changes that occur
in the organization, composition, and mechanical properties of the extracellular matrix …

The aortic valve regulates unidirectional flow of oxygenated blood to the myocardium and
arterial system. The natural anatomical geometry and microstructural complexity ensures …

Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …

Cardiac valves function in a mechanically complex environment, opening and closing close
to a billion times during the average human lifetime, experiencing transvalvular pressures …

Surgical replacement of diseased heart valves by mechanical and tissue valve substitutes is
now commonplace and enhances survival and quality of life for many patients. However …

Fibrotic cardiac disease, a leading cause of death worldwide, manifests as substantial loss
of function following maladaptive tissue remodeling. Fibrosis can affect both the heart valves …

Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and
mortality and, given its association with age, the prevalence of CAVD is expected to continue …