On the importance of parenting in externalizing disorders: an evaluation of indirect genetic effects in families
Background Theoretical models of the development of childhood externalizing disorders
emphasize the role of parents. Empirical studies have not been able to identify specific …
emphasize the role of parents. Empirical studies have not been able to identify specific …
Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
Neuropsychiatric genome-wide association studies (GWASs), including those for autism
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …
spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the …
Ordered multinomial regression for genetic association analysis of ordinal phenotypes at Biobank scale
Logistic regression is the primary analysis tool for binary traits in genome‐wide association
studies (GWAS). Multinomial regression extends logistic regression to multiple categories …
studies (GWAS). Multinomial regression extends logistic regression to multiple categories …
Disentangling direct and indirect genetic effects from partners and offspring on maternal depression using trio-GCTA
Maternal depressive symptoms are highly prevalent and can negatively impact affected
individuals and family members. Understanding etiological influences on maternal …
individuals and family members. Understanding etiological influences on maternal …
[HTML][HTML] Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain
Genomic regulatory elements active in the developing human brain are notably enriched in
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …
genetic risk for neuropsychiatric disorders, including autism spectrum disorder (ASD) …
GeneticsMakie. jl: A versatile and scalable toolkit for visualizing locus-level genetic and genomic data
With the continued deluge of results from genome-wide association and functional genomic
studies, it has become increasingly imperative to quickly combine and visualize different …
studies, it has become increasingly imperative to quickly combine and visualize different …
Heritability of interpack aggression in a wild pedigreed population of North American grey wolves
Aggression is a quantitative trait deeply entwined with individual fitness. Mapping the
genomic architecture underlying such traits is complicated by complex inheritance patterns …
genomic architecture underlying such traits is complicated by complex inheritance patterns …
A Polynesian-specific missense CETP variant alters the lipid profile
J Moors, M Krishnan, N Sumpter, R Takei… - Human Genetics and …, 2023 - cell.com
Identifying population-specific genetic variants associated with disease and disease-
predisposing traits is important to provide insights into the genetic determinants of health …
predisposing traits is important to provide insights into the genetic determinants of health …
A gene-level test for directional selection on gene expression
Most variants identified in human genome-wide association studies and scans for selection
are noncoding. Interpretation of their effects and the way in which they contribute to …
are noncoding. Interpretation of their effects and the way in which they contribute to …
Iterative hard thresholding in genome-wide association studies: Generalized linear models, prior weights, and double sparsity
Background Consecutive testing of single nucleotide polymorphisms (SNPs) is usually
employed to identify genetic variants associated with complex traits. Ideally one should …
employed to identify genetic variants associated with complex traits. Ideally one should …