Inflammation in neurodegenerative disease—a double-edged sword
T Wyss-Coray, L Mucke - Neuron, 2002 - cell.com
Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …
Complement components of the innate immune system in health and disease in the CNS
P Gasque, YD Dean, EP McGreal, J VanBeek… - …, 2000 - Elsevier
The innate immune system and notably the complement (C) system play important roles in
host defense to recognise and kill deleterious invaders or toxic entities, but activation at …
host defense to recognise and kill deleterious invaders or toxic entities, but activation at …
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
Microarray analysis of multiple sclerosis (MS) lesions obtained at autopsy revealed
increased transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 …
increased transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 …
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
T Wyss-Coray, F Yan, AHT Lin… - Proceedings of the …, 2002 - National Acad Sciences
Abnormal accumulation of β-amyloid (Aβ) in Alzheimer's disease (AD) is associated with
prominent brain inflammation. Whereas earlier studies concluded that this inflammation is …
prominent brain inflammation. Whereas earlier studies concluded that this inflammation is …
T‐and B‐cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis
A Iglesias, J Bauer, T Litzenburger, A Schubart… - Glia, 2001 - Wiley Online Library
The identification of myelin oligodendrocyte glycoprotein (MOG) as a target for autoantibody‐
mediated demyelination in experimental autoimmune encephalomyelitis (EAE) resulted in …
mediated demyelination in experimental autoimmune encephalomyelitis (EAE) resulted in …
The spectrum of complement alternative pathway‐mediated diseases
VM Holers - Immunological reviews, 2008 - Wiley Online Library
The complement system has once again come into prominence in the therapeutic
development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab …
development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab …
Inhibition of complement C3 signaling ameliorates locomotor and visual dysfunction in autoimmune inflammatory diseases
L Xu, H Xu, S Chen, W Jiang, SK Afridi, Y Wang… - Molecular Therapy, 2023 - cell.com
Neuromyelitis optica (NMO) is an autoimmune inflammatory disease of the central nervous
system (CNS) characterized by transverse myelitis and optic neuritis. The pathogenic serum …
system (CNS) characterized by transverse myelitis and optic neuritis. The pathogenic serum …
Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma
A Bosco, SR Anderson, KT Breen, CO Romero… - Molecular Therapy, 2018 - cell.com
Dysregulation of the complement system is implicated in neurodegeneration, including
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …
human and animal glaucoma. Optic nerve and retinal damage in glaucoma is preceded by …
B cells and antibodies in CNS demyelinating disease
AH Cross, JL Trotter, JA Lyons - Journal of neuroimmunology, 2001 - Elsevier
There is much evidence to implicate B cells, plasma cells, and their products in the
pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is …
pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is …
Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating …
G Raivich, R Banati - Brain Research Reviews, 2004 - Elsevier
Microglia and macrophages, one a brain-resident, the other a mostly hematogenous cell
type, represent two related cell types involved in the brain pathology in multiple sclerosis …
type, represent two related cell types involved in the brain pathology in multiple sclerosis …