Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Leishmaniasis due to Leishmania infantum (syn. L. chagasi) infection is a zoonotic disease
present mainly in Mediterranean basin, central Asia and Brazil. Besides a limited number of …

Human visceral leishmaniasis (VL) results in a severe and potentially fatal systemic disease,
accompanied by cellular immune depression. The production of IL‐10 correlates with …

Several species of Leishmania cause human diseases that range from self-healing
cutaneous lesions to fatal visceral leishmaniasis, mucosal leishmaniasis and diffuse …

Human vaccination against leishmaniasis using live Leishmania was used in Middle East
and Russia (1941–1980). First-generation vaccines, composed by killed parasites induce …

Post-kala-azar dermal leishmaniasis (PKDL) is a common complication of visceral
leishmaniasis (VL) caused by Leishmania donovani. Because of its possible role in …

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune
dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine …

Neutrophils are the most crucial cells for early defence against infections. When
appropriately activated, they can kill obligate intracellular pathogens such as Leishmania …

Visceral leishmaniases (VL) or kala-azar is the most dreaded and devastating amongst the
various forms of leishmaniases. The disease, though localized in certain areas only, has …

This review discusses the roles played by natural CD4+ CD25+ regulatory T cells (natural
Tregs) during parasitic infections. Natural Tregs may limit the magnitude of effector …