In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Simple Summary Ferroptosis is a type of cell death, which is morphologically and
mechanistically distinct from other type of cell death pathways such as apoptosis and …

Fatty acid isomers are responsible for an under-reported lipidome diversity across all
kingdoms of life. Isomers of unsaturated fatty acids are often masked in contemporary …

Marine ecosystems are rich in “omega-3” long-chain (C 20-24) polyunsaturated fatty acids
(LC-PUFA). Their production has been historically accepted to derive mostly from marine …

Ferroptosis is a form of nonapoptotic cell death for which key regulators remain unknown.
We sought a common mediator for the lethality of 12 ferroptosis-inducing small molecules …

Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …

Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human
health and development, and numerous fatty acid desaturases play key roles in synthesizing …

Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …