With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

The 2016 revision of the World Health Organization classification of tumors of hematopoietic
and lymphoid tissues is characterized by a closer integration of morphology and molecular …

Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive
immunity, and increased inflammation and myeloid pathologies,. Age-related changes in …

Inflammation coordinates tissue regeneration via damaged cell removal and stem cell
activation. Hematopoietic stem cells (HSCs) survive inflammatory stress that kills other blood …

Unexplained blood cytopenias, in particular anemia, are often found in older persons. The
relationship between these cytopenias and myeloid neoplasms like myelodysplastic …

Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of
mutated haematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal …

Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral
heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to …

Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving
transcriptional heterogeneity. However, its application to studying cancerous tissues is …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …