Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …

Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method
used to isolate high-affinity single stranded oligonucleotides from a large random sequence …

In the last three decades, oligonucleotides have been extensively investigated as probes,
molecular ligands and even catalysts within therapeutic and diagnostic applications. The …

Targeted therapeutics underwent a revolution with the entry of monoclonal antibodies in the
medical toolkit. Oligonucleotide aptamers form another family of target agents that have …

Systematic evolution of ligands by exponential enrichment (SELEX) is a well-established
technology for the screening of aptamers binding to various targets with relatively high …

Aptamers are short non-coding, single-stranded oligonucleotides (RNA or DNA) developed
through Systematic Evolution of Ligands by Exponential enrichment (SELEX) in vitro. Similar …

The tunability of SELEX procedure is an essential feature to supply bioaffinity receptors
(aptamers) almost on demand for analytical and therapeutic purposes. This longstanding …

Aptamers are high affinity single-stranded DNA/RNA molecules, produced by a
combinatorial procedure named SELEX (Systematic Evolution of Ligands by Exponential …

Cell cycle is regulated through numerous signaling pathways that determine whether cells
will proliferate, remain quiescent, arrest, or undergo apoptosis. Abnormal cell cycle …