Abstract Background Group B Streptococcus (GBS) remains a leading cause of neonatal
sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis …

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …

Exposure to antibiotics in the first days of life is thought to affect various physiological
aspects of neonatal development. Here, we investigate the long-term impact of antibiotic …

Objective To assess the epidemiology of blood culture-proven early-(EOS) and late-onset
neonatal sepsis (LOS). Study design All newborn infants admitted to tertiary care neonatal …

Early neonatal death (ENND), defined as the death of a newborn between zero and seven
days after birth, represents 73% of all postnatal deaths worldwide. Despite a 50% reduction …

Background Up to 7% of term and late-preterm neonates in high-income countries receive
antibiotics during the first 3 days of life because of suspected early-onset sepsis. The …

Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …

Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers, but their
diagnostic advantage for neonatal early-onset (EOS) or late-onset (LOS) sepsis is …

Abstract Altogether, 20–30% of women receive intrapartum antibiotic prophylaxis (IAP) to
prevent sepsis in infants and 2–5% of newborn infants receive antibiotics due to suspected …

Importance The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification
tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on …