Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …

Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Despite widespread use of the bacille Calmette–Guérin (BCG) vaccine, tuberculosis (TB)
remains a leading cause of global mortality from a single infectious agent (Mycobacterium …

Abstract Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote
inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial …

Neutrophils are immune cells that are well known to be present during many types of lung
diseases associated with acute respiratory distress syndrome (ARDS) and may contribute to …

Autophagy is a cell biological pathway affecting immune responses. In vitro, autophagy acts
as a cell-autonomous defense against Mycobacterium tuberculosis, but its role in vivo is …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

Background The exact role of neutrophils in the pathogenesis of TB is poorly understood.
Recent evidence suggests that neutrophils are not simply scavenging phagocytes in …

Background & Aims: Celiac disease is an immune-mediated enteropathy triggered by
gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent …