Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …

The mechanistic target of rapamycin (mTOR) is a central regulator of cellular homeostasis
that integrates environmental and nutrient signals to control cell growth and survival. Over …

Biomolecular condensates concentrate molecules to facilitate basic biochemical processes,
including transcription and DNA replication. While liquid-like condensates have been …

Naked mole–rats are among the mammalian champions of hypoxia tolerance. They evolved
adaptations centered around reducing metabolic rate to overcome the challenges …

Naked mole-rats are among the few mammals with the ability to endure severe hypoxia.
These unique rodents use metabolic rate depression along with various molecular …

Over the previous several decades, many non-traditional research models have offered new
avenues of exploration for biomedical research. The promise of these animals is primarily …

From squid at the bottom of the ocean to humans at the top of mountains, animals have
adapted to diverse oxygen-limited environments. Surviving these challenging conditions …

Metabolic flexibility in mammals enables stressed tissues to generate additional ATP by
converting large amounts of glucose into lactic acid; however, this process can cause …

Naked mole-rats (NMRs) are a long-lived animal that do not develop age-related diseases
including neurodegeneration and cancer. Additionally, NMRs have a profound ability to …

Many animals routinely make energetic trade‐offs to adjust to environmental demands and
these trade‐offs often have significant implications for survival. For example, environmental …