Adaptations to a hypoxic lifestyle in naked mole-rats
ME Pamenter - Journal of Experimental Biology, 2022 - journals.biologists.com
Hypoxia is one of the strongest environmental drivers of cellular and physiological
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …
adaptation. Although most mammals are largely intolerant of hypoxia, some specialized …
[HTML][HTML] mTOR signaling in metabolic stress adaptation
The mechanistic target of rapamycin (mTOR) is a central regulator of cellular homeostasis
that integrates environmental and nutrient signals to control cell growth and survival. Over …
that integrates environmental and nutrient signals to control cell growth and survival. Over …
Local translation in nuclear condensate amyloid bodies
PR Theodoridis, M Bokros, D Marijan… - Proceedings of the …, 2021 - National Acad Sciences
Biomolecular condensates concentrate molecules to facilitate basic biochemical processes,
including transcription and DNA replication. While liquid-like condensates have been …
including transcription and DNA replication. While liquid-like condensates have been …
Hypoxic naked mole–rat brains use microRNA to coordinate hypometabolic fuels and neuroprotective defenses
H Hadj‐Moussa, ME Pamenter… - Journal of Cellular …, 2021 - Wiley Online Library
Naked mole–rats are among the mammalian champions of hypoxia tolerance. They evolved
adaptations centered around reducing metabolic rate to overcome the challenges …
adaptations centered around reducing metabolic rate to overcome the challenges …
Naked mole-rats resist the accumulation of hypoxia-induced oxidative damage
H Hadj-Moussa, L Eaton, H Cheng… - … and Physiology Part A …, 2022 - Elsevier
Naked mole-rats are among the few mammals with the ability to endure severe hypoxia.
These unique rodents use metabolic rate depression along with various molecular …
These unique rodents use metabolic rate depression along with various molecular …
Supermole-rat to the rescue: Does the naked mole-rat offer a panacea for all that ails us?
ME Pamenter, H Cheng - Comparative Biochemistry and Physiology Part A …, 2022 - Elsevier
Over the previous several decades, many non-traditional research models have offered new
avenues of exploration for biomedical research. The promise of these animals is primarily …
avenues of exploration for biomedical research. The promise of these animals is primarily …
The OxymiR response to oxygen limitation: a comparative microRNA perspective
H Hadj-Moussa, KB Storey - Journal of Experimental Biology, 2020 - journals.biologists.com
From squid at the bottom of the ocean to humans at the top of mountains, animals have
adapted to diverse oxygen-limited environments. Surviving these challenging conditions …
adapted to diverse oxygen-limited environments. Surviving these challenging conditions …
[HTML][HTML] Low cancer incidence in naked mole-rats may be related to their inability to express the warburg effect
P Freire Jorge, ML Goodwin, MH Renes… - Frontiers in …, 2022 - frontiersin.org
Metabolic flexibility in mammals enables stressed tissues to generate additional ATP by
converting large amounts of glucose into lactic acid; however, this process can cause …
converting large amounts of glucose into lactic acid; however, this process can cause …
PPARα and PPARγ signaling is enhanced in the brain of the naked mole-rat, a mammal that shows intrinsic neuroprotection from oxygen deprivation
MR Pergande, VG Amoroso, TTA Nguyen… - Journal of Proteome …, 2021 - ACS Publications
Naked mole-rats (NMRs) are a long-lived animal that do not develop age-related diseases
including neurodegeneration and cancer. Additionally, NMRs have a profound ability to …
including neurodegeneration and cancer. Additionally, NMRs have a profound ability to …
Does hypometabolism constrain innate immune defense?
KL Kadamani, SM Logan, ME Pamenter - Acta Physiologica, 2024 - Wiley Online Library
Many animals routinely make energetic trade‐offs to adjust to environmental demands and
these trade‐offs often have significant implications for survival. For example, environmental …
these trade‐offs often have significant implications for survival. For example, environmental …