Although modern techniques such as two-photon microscopy can now provide cellular-level
three-dimensional imaging of the intact living brain, the speed and fields of view of these …

Magnetic resonance imaging (MRI) has rapidly become an important tool in clinical
medicine and biological research. Its functional variant (functional magnetic resonance …

Optical approaches to investigate cerebral function and metabolism have long been applied
in invasive studies. From the neuron cultured in vitro to the exposed cortex in the human …

There is a wide range of functional magnetic resonance imaging (fMRI) study designs
available for the neuroscientist who wants to investigate cognition. In this manuscript we …

During the last few decades, neuroscientists have benefited from the emergence of many
powerful functional imaging techniques that cover broad spatial and temporal scales. We …

Changes in neuronal activity are accompanied by the release of vasoactive mediators that
cause microscopic dilation and constriction of the cerebral microvasculature and are …

Functional magnetic resonance imaging (fMRI) is currently combined with
electrophysiological methods to identify the relationship between neuronal activity and the …

Analysis of the spatiotemporal coupling between neuronal activity and cerebral blood flow
requires the precise measurement of the dynamics of RBC flow in individual capillaries that …

Recent advances in brain imaging techniques, including functional magnetic resonance
imaging (fMRI), offer great promise for noninvasive mapping of brain function. However, the …

An understanding of the relationship between changes in neural activity and the
accompanying hemodynamic response is crucial for accurate interpretation of functional …